癌症
Zon 课题组用斑马鱼胚胎进行药物筛选, 发现了双氢乳清酸酯脱氢酶 (Dihydroorotate dehydrogenase, DHODH)的抑制剂, 比如来氟米特(Leflunomide), 能抑制神经脊细胞发育。在哺乳动物模型里的实验表明, 通过抑制DHODH 可以有效抑制黑素瘤在体外和体内的增殖。Leflunomide 也被批准进入了临床实验, 与Vemurafenib 联合用药治疗黑素瘤(ClinicalTrials.gov Identifier NCT01611675)。
（Patton, E.E., Widlund, H.R., Kutok, J.L., Kopani, K.R., Amatruda, J.F., Murphey, R.D., Berghmans, S., Mayhall, E.A., Traver, D., Fletcher, C.D., et al. (2005). BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Current biology : CB 15, 249-254
